Browsing Pharmacy College Research by Issue Date

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Reactive Dicarbonyls in Human Cataractous Nuclei

El Mehdi, Eman; Sahoo, Rashmirekha; A Ahmed, Musa; Mohamed rghigh, Abir; Al Geilania, Abdelsalam; Sahoo, Soumendra (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al -Arab Medical Science University, Benghazi, Libya, 2008-06-02)

Non-enzymic glycation of long-lived proteins has been implicated in several age related and diabetes related complications, including cataract. Dicarbonyl compounds such as methylglyoxal and glyoxal have been identified ...
Reactive Dicarbonyls in removed cataractous lens nuclei, aqueous humor and plasma of senile cataract patients

Sahoo, Soumendra; Sahoo, Rashmirekha; El Mehendi, Iman; Abuajila Ahmad, Musa (JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL SCIENCES, 2012-09-23)

Background:- Dicarbonyl compounds such as methylglyoxal and glyoxal have been identified as the predominant source for the formation of advanced glycation end products (AGE) in various tissues contributing to aging and ...
Three-Dimensional Presentations of Factorial Experimentation Data of Extrusion – Spheronization

El‑Mahdi, Idris; A El-Shehebia, Tariq (Lebda Medical Journal, 2016-04-18)

Extrusion – spheronization technology is one of the major methods for production of multiparticulates in the pharmaceutical industry. The difficulty in this method is how to develop a formulation ...
Effect of spheronizer plate design on the spheronization of ketoprofen

A El-Shhibia, Salma; M.El-Mahdi, Idris (Department of Pharmaceutics, Faculty of Pharmacy, University of Benghazi, 2017-07-26)

Spheronization is a rapid process for production of microspheres. The process involves the dry mixing ofdrug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plasticmass suitable for ...
Bioavailability of Oral Colon-Specific Ketoprofen Microcapsules

M El-Mahdi, Idris; A El-Shhibia, Salma (Lebda Medical Journal, 2017-10-02)

Oral, colon-specific drug delivery has attracted much interest recently. It is of considerable advantage to have an oral drug delivery system that could be targeted to the colon. This could be either for the local treatment ...
Al-Zaytoonah University of Jordan and The University of Toledo Seventh International Pharmaceutical Conference (ZTIPC 2019)

Al-Qirim, prof.Tariq; Al-Qerem, Dr. Waleed; Sari, prof.youssef; Bryant-Friedrich, Dr. Amanda; Hikmat, Dr. Suhair; Harb, Dr. Mohammad; Mohamed, Dr. Negia; Abul-Futooh, Dr. Hassan; Ali Al-Qirim, MSc. Rania; Abu Sheikha, Prof. Ghassan; Al-Essa, Dr. Luay; Hamed, Dr. Rania; Al-Hiari, Prof. Yusuf; Al Bawab, Dr. Abdel Qader; Hamadneh, Dr. Lama; Alhusban, Dr. Ala` (Al-Zaytoonah University of Jordan and The University of Toledo Seventh International Pharmaceutical Conference (ZTIPC 2019), 2019-11-07)
Computational, Pharmacological Evaluation and Comparative Similarity against Chloroquine for Some New Designed Hybridized Molecules and their Potential Use as Antiviral against COVID-19 and Malaria

Najar, Adel; MK Omar, Ruwida; Bobtaina, Eman (Department of Chemistry, Benghazi University, Benghazi, Libya, 2020-06-15)

Starting from the concept of "similar molecules exert similar biological activities" to modify structures of biologically active molecules or readily available drugs to improve their therapeutic activity or reduce side ...
Pryazolylpyridine and Triazolylpyridine derivative of hydroxychloroquine as Potential Therapeutic against COVID-19: Theoretical Evaluation

M.K. Omar, Ruwida; M. Najar, Adel; Bobtaina, Eman; F. Elsheikh, Awad (Department of Pharmaceutical chemistry, Benghazi University, Libya, 2020-08-16)

In attempt to improve the biological activity of the well-known drug hydroxychloroquine (HQC), eight derivatives (HQ1-4Py – HQ8-4Py) based on the core of HQC were design and their electronic properties including frontier ...
Review of Biological Properties, Composition and Toxicity of Annonna Muricata

A. Algeryani, Safa; F. Al Shwihdy, Najwa; Omar, Ruwida; El-shinitri, Nouha; A. Alnajjar, Radwan (Department of Medicinal Chemistry, Faculty of Pharmacy, 2020-09-24)

Annona muricata also known as a Grviola is a fruit tree with a long history of traditional use. A. muricata has a wide array of ethnomedicinal activities and containing wide range of chemical compounds including Alkaloids ...
Bicyclo[1.1.1]Pentane as Phenyl Substituent in Atorvastatin Drug to improve Physicochemical Properties: Drug-likeness, DFT, Pharmacokinetics, Docking, and Molecular Dynamic Simulation

Alnajjar, Radwan; Mohamed, Najwa; Kawafi, Nagwa (Department of Chemistry, Faculty of Science, University of Benghazi, Libya, 2020-11-09)

Hyperlipidemia influences on numerous diseases, such as atherosclerosis, hypertension, and diabetes mellitus, however it still treatable. Atorvastatin is one of the most common statins; yet, it has poor solubility due to ...
Molecular Modeling Analysis of Atorvastatin Drug Enantiomers

Alnajjar, Radwan; Kawafi, Nagwa; Elmhdw, Maraia; Kamunya, Stephanie; Eltumi, Salem; F. Mohamed, Najwa (Department of Pharmaceutical chemistry, Benghazi University, Libya, 2020-12-02)

In this work, Atorvastatin, one of the most selling drugs in the world for cardiovascular disease, was studied theoretically. Density functional theory (DFT) calculations were carried out on the four optical enantiomers ...

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