Abstract:
The starting compound 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one
(4) was prepared from the reaction of 2-acetylbenzo[f]coumarin-3-one (3) with
DMFDMA in refluxing xylene. Reaction of enaminone4 with 6-aminothiouracil in
acetic acid afforded 2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 6.The
latter compound was used as the key molecule for synthesis of
pyridotriazolopyrimidinones9a-d via its reactionwith various hydrazonoyl halides in
dioxane and triethylamine.
