The Comparative Between Gut Microbiota in Type 2 Patients Diabetes and Health People

Abstract

The Diabetes it is a major contributor to the development of many pathological processes including hypertension, hyperlipidemia, and cardiovascular diseases. both animal and human studies indicates that gut microbial change is associated with diabetes, but such an association with T2DM in Libyan people is not known. Therefore, the aim of present study is to recognize if there is a difference in the bacterial composition between Libyan diabetic patients and a healthy control. Also, to find whether there is a relationship between bacterial composition and diverse factors such as FBS, HbA1c, and lipid profile and body composition. Two groups of participated in this study including 20 patients with type 2 diabetes and 28 healthy control subjects were involved. The fecal microbiota structure at level of species was investigated by using conventional culture method. There was significant difference in gut bacteria between diabetic patients and healthy control. The relative abundance of B. vulgatus, and B. rodentium were significantly declined in the diabetic group compared to non-diabetic group (P = 0.008, P = 0.018) but B. vulgatus negatively and significantly correlated to level of HDL-C (P = 0.015). Moreover, the relative abundance of L. acidophilus reduced significantly (P = 0.02) and correlated positively and significantly with Fasting blood sugar (P = 0.001) and HbA1c (P = 0.016) in diabetic patients compared to the healthy control group. Our results show that T2DM is associated with compositional alterations in gut microbiota. B. vulgatus, B. rodentium and L. acidophilus B. may be possible indicators of T2DM. The interaction of specific gut microbiota with FBG, HbA1c, and HDL-C should be considered as potential interest for future studies to develop better approaches for the prevention and treatment of T2DM by modulation of gut microbiota.