The extracellular calcium-sensing receptor: effects on epithelial (E)-cadherin and a role in cell adhesion and cell-to-cell coupling in the pancreatic islet

Abstract

The Calcium-sensing Receptor (CaR) was first identified/cloned in the parathyroid gland (Brown et al,1993). CaR is a seven trans-membrane spanning, G-protein coupled receptor known to be involved in the regulation of systemic calcium