Abstract:
Background: Using anti-retroviral therapy for HIV positive subjects has been reported to be linked to metabolic abnormalities such as altered
serum lipid profile parameters. Materials and Methods: This study involved a hundred-one Libyan ART-treated HIV-1 subjects were on
Different ART regimens and twenty-one untreated "Naïve" from Benghazi Medical Center and Benghazi center for infectious diseases and
immunology during 2018-2019 and seventy age-matched HIV-negative subjects used as control. Aim: to assess total cholesterol (TC),
triglycerides (TG), lipoproteins and other investigations such as viral load, CD4 and CD8. Results; TC, TG and LDL-C levels of HIV positive
(122) subjects were highly significant (P <0.001) increased compared to HIV-negative subjects, whereas, HDL-C and LDL/HDL risk ratio were
not significantly altered. TC, TG and LDL-C in the 4 ART-treated HIV subgroups were significantly (P <0.001) increased compared with ARVNaïve
and control groups. The CD4 count in the ARV treated-HIV subjects were significantly (P <0.014) lower compared CD4 count of
untreated HIV group. Conclusion: The findings in the present study were in accordance with many other studies and suggests an association
between HIV and dyslipidemia (specifically when protease inhibitor used) that is potentiated by receiving ART regimens. Monitoring lipid
profile continuously become a necessity during the ART application.
