Abstract:
A group of patients with and hyperlipidemia were divided
into male and female groups and further subdivided into
3 groups. These groups received, either simvastatin (20
mg daily), Omega3-fatty acid (2g/day), or both. The
blood pressure and lipid profile were measured before
and after 4 weeks of treatment. Our data showed that
treatment with simvastatin did not produce significant
effect on blood pressure, however the blood pressure
was significantly reduced in patients received omega
3-fatty acid or simvastatin plus omega3-fatty acid. The
total cholesterol (TC), triglycerides (TG), and low density
lipoprotein (LDL) significantly decreased in all treated
groups. The high density lipoprotein (HDL) significantly
increased in all treated groups except in the group of
males receiving simvastatin. Alanine transaminase
(ALT) increased significantly in female and male groups
receiving simvastatin, but significantly decreased in same
groups receiving omega 3-fatty acid and in the males
receiving simvastatin plus omega3-fatty acid. The aspartate
transaminase (AST) levels significantly decreased in all
treated groups except in the female group given omega3-
fatty acid. The alkaline phosphatase (ALP) significantly
increased only in the groups given simvastatin alone.
The levels of urea and creatinine were not affected in all
groups. In our prospective study we found that simvastatin
decreased TC, TG and LDL, and resulted in elevation
of liver transaminases. Omega3- fatty acid alone or in
combination with simvastatin has similar effect on lipid
profile and it significantly reduces blood pressure without
affecting liver or renal function.
