DSpace Repository

Stem cells transplantation as a treatment for Parkinson’s disease

Show simple item record

dc.contributor.author Elbouri, Narmin M
dc.contributor.author Abdelmalik, Aisha M
dc.contributor.author Animasawun, Rashidat K
dc.date.accessioned 2020-10-01T20:10:03Z
dc.date.available 2020-10-01T20:10:03Z
dc.date.issued 2020-04-14
dc.identifier.issn 2663-1407
dc.identifier.uri http://repository.uob.edu.ly/handle/123456789/1286
dc.description.abstract Parkinson’s disease is a progressive disorder of movement that occurs mainly in the elderly. It is the second most common neurodegenerative disease after Alzheimer’s disease. Current pharmacological therapies focus on the substitution of dopamine, although this gives therapeutic benefits, its continued use is associated with reduced clinical benefits and it may be associated with a major motor complication known as dyskinesia. Due to their ability to transdifferentiate to dopamine producing cells, stem cell transplantation could be a long-term solution for the disease. Although many preclinical studies showed that different types of stem cells could improve the motor behavior in animal models of Parkinson's disease, there seem to be some technical challenges in the way of testing these cells on patients with the disease. This review highlights the recent advances in the use of three different types of stem cells; embryonic stem cells, neural stem cells, and other stem precursor cells. It particularly focuses on the complications that may arise from using each type of cell, summarizing some of the preclinical studies. Recent clinical studies using different types of cells were also reviewed. en_US
dc.language.iso en en_US
dc.publisher Universty of Benghazi en_US
dc.relation.ispartofseries Volume 11, Issue 1, February 2020;1
dc.subject Parkinson's disease en_US
dc.subject stem cells en_US
dc.subject neural stem cells en_US
dc.subject mesenchymal stem cells en_US
dc.subject embryonic stem cells en_US
dc.subject pluripotent stem cells en_US
dc.subject clinical trials en_US
dc.title Stem cells transplantation as a treatment for Parkinson’s disease en_US
dc.type Working Paper en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account